Synthego

REDWOOD CITY, CA · Founded 2012 · Biotech · Acquired

CRISPR guide RNAs and molecular biology reagents for research and diagnostics

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Updated Oct 23, 2026 · synthego.com

Sector: Biotech
Headquarters: REDWOOD CITY, CA
Founded: 2012
Latest Form D: $106M, Oct 2018
Total capital: $159M

Federal grants: None on recordNo awards found in SBIR/STTR, NIH, NSF or DoD records.
Private capital raised: $156M; 5 Form D · last Oct 2018; 96 months since last filing
Federal contracts: $3.2M; 60 awards · Health and Human S, Veterans Affairs, Environmental Prot; Rank in Biotech#105 of 4373
Granted patents: 14; 26 pending · first 2018; Rank in peer group#18 of 342

Capital timeline

Latest events

Jun 2024Federal contractHealth and Human S · Niaaa - Gene Variant Editing Services$69K
May 2024Federal contractHealth and Human S · Custom Sgrna Crispr Library$25K
May 2024Federal contractHealth and Human S · Knockin-small, Cell Clone, Immortalized$13K
May 2024Federal contractHealth and Human S · Nichd - Service For Custom Knockin Cell Clones$11K
Apr 2024Federal contractHealth and Human S · High-throughput Screening To Identify Modulators Of The Expression Of Human HIF1 And HIF2$23K
Feb 2024Federal contractHealth and Human S · Knockin-small, Cell Clone, Ipsc, Synthego Supplied Vial For Nidcr$26K
Feb 2024Federal contractHealth and Human S · 24-005500 Dr. Martina Requires Knock-in Cell Line Generation Services In Order To Perform Cell Biology Experiments.$13K
Oct 2018Private capital raisedForm D · SEC · 5th filing$106M
Jan 2017Private capital raisedForm D · SEC · 4th filing$40.7M
Jul 2013Private capital raisedForm D · SEC · 3rd filing$8.3M
Aug 2012Private capital raisedForm D · SEC · 2nd filing$250K
Jun 2012Private capital raisedForm D · SEC · 1st filing$205K

Show 53 earlier federal awards

Sep 2023Federal contractHealth and Human S · Sythego - Knock-in And Knock-out Cell Clones$34K
Sep 2023Federal contractHealth and Human S · Knockin-small, Cell Clone, Ipsc, Synthego Supplied$23K
Aug 2023Federal contractHealth and Human S · SYNTHEGO:1293873 [23-004216] 01-KNOCKIN-SMALL, Cell Clone, Immortalized, Synthego Supplied, Vial (#)estimated Turnaround Time: 17 Weeks Species: Human Cell Line: THP-1 Type Of Knock In: Snv/codon Change Edit In: Protein Coding Sequence Chromosome: C$23K
Aug 2023Federal contractHealth and Human S · SYNTHEGO:1293873 [23-006276]$60K
Jul 2023Federal contractHealth and Human S · Nichd: Services: Endogenous CLN3 1-KB Deletion$15K
Jul 2023Federal contractHealth and Human S · Identify Modifiers Of SMCHD1 Activity In Human Cranial Placode Cells For Ncats$22K
Jun 2023Federal contractHealth and Human S · Knockout-single, Cell Clone, Immortalized, Synthego Supplied, Vial$17K
Apr 2023Federal contractHealth and Human S · Crispr-edited Ips Cells$88K
Mar 2023Federal contractEnvironmental Prot · Immortalized Knockout Cell Pools$22K
Mar 2023Federal contractHealth and Human S · Engineer Human Luhmes Cell Lines To Mutate Three Neuronal Genes.$11K
Sep 2022Federal contractHealth and Human S · Knockout-single, Cell Clone, Immortalized, User Supplied$18K
Aug 2022Federal contractHealth and Human S · Nichd - Services To Create Edited Cells$25K
Aug 2022Federal contractHealth and Human S · Human Ubiquitin Ligases (E1, E2, E3)$25K
Sep 2021Federal contractHealth and Human S · Custom Knockin Cell Lines$17K
Sep 2021Federal contractHealth and Human S · Custom Knockin Cell Lines$17K
Sep 2021Federal contractHealth and Human S · Custom Knockin Cell Lines$28K
Sep 2021Federal contractHealth and Human S · Nichd - Gene Knockout Services$17K
Sep 2021Federal contractHealth and Human S · The Process To Generate These Cell Lines Is Highly Time And Resource Consuming. Additionally, Our Laboratory Does Not Have The Expertise And Technical Resources Needed To Perform The Work$24K
Aug 2021Federal contractHealth and Human S · Knockout-single, Cell Clone, Immortalized, Synthego Supplied, Vial$24K
Aug 2021Federal contractHealth and Human S · Knockout-single, Cell Clone, Immortalized, Synthego Supplied, Vial$24K
Aug 2021Federal contractHealth and Human S · This Firm Fixed Price Purchase Order Is Awarded For Knockin-small, Cell Clone, Ipsc To SYNTHEGO:1293873 In The Amount Of $18,150.00 Quote# Q-00726$18K
Aug 2021Federal contractHealth and Human S · Lab Requires Knock Out Cell Line Generation Services In Order To Perform Cell Biology Experiments.$17K
Aug 2021Federal contractHealth and Human S · To Procure Crispr Gene-editing Of The ACVR1 And TGFBR1 Genes In Endometrial Cancer Cell Lines For Nhgri.$61K
Jul 2021Federal contractHealth and Human S · Knockout-single, Cell Clone, Ipsc, Synthego Supplied, Vial Custom Ipsc Homozygous Ko For HELZ2 Isoform 1 Quote Q-00888$18K
Jun 2021Federal contractHealth and Human S · Ipsc Genome Engineering$26K
Jan 2021Federal contractHealth and Human S · Ipsc Genome Engineering$54K
Sep 2020Federal contractHealth and Human S · The Purpose Of This Purchase Order Is To Acquire Custom Engineering Of The Luhmes Cell Line To Knockin Hibit Reporter Into Genomic MT1G Gene.$24K
Sep 2020Federal contractHealth and Human S · Development Of Ips Report Cell Lines Expressing Hibit Atspecified Heal-related Genes$224K
Sep 2020Federal contractHealth and Human S · Development Of Ips Report Cell Lines Expressing Hibit At Specified Target Genes$224K
Aug 2020Federal contractHealth and Human S · Advanced Rna 100, 33MG, MAGT1$25K
Aug 2020Federal contractHealth and Human S · Cell Line Generation$9K
Aug 2020Federal contractHealth and Human S · SYNTHEGO:1293873 [20-008632]$47K
Aug 2020Federal contractHealth and Human S · Standard Arrayed Crispr Library$17K
Jul 2020Federal contractHealth and Human S · Whole Human Genome Arrayed Crispr Screening Library$356K
Jun 2020Federal contractHealth and Human S · Ipsc Knockin, Crispr Genome Engineering And Related Services$25K
Feb 2020Federal contractVeterans Affairs · Off-site R&d: Knockout Cell Pools$58K
Feb 2020Federal contractHealth and Human S · Knockout Service Sof Two Genes (B2M And IFNGR1) From Two Cancer Cell Lines$13K
Nov 2019Federal contractVeterans Affairs · Crispr Stem Cell Engineering$82K
Sep 2019Federal contractVeterans Affairs · Research And Development_ Reprogramming Of Commercially Available Knockout Cell Lines Into Induced Pluripotent Stem Cell And Characterization For Pluripotency By Immunocytochemistry, Sgrna ? Pcr, And Karyotyping.$40K
Sep 2019Federal contractHealth and Human S · Ipsc Engineering Services$509K
Sep 2019Federal contractHealth and Human S · To Obtain Sgrna Libraries From Synthego.$87K
Sep 2019Federal contractHealth and Human S · Gene Editing Service$189K
Sep 2019Federal contractHealth and Human S · Create Genetically Modified Cell Lines$36K
Aug 2019Federal contractHealth and Human S · Creation Of Knockin Clonal Cell Line$16K
Aug 2019Federal contractHealth and Human S · Custom Crispr Knock In Generation Of A Cell Line Synthego Quote # 1869).$18K
Jun 2019Federal contractHealth and Human S · SYNTHEGO:1293873 [19-046007]$25K
May 2019Federal contractHealth and Human S · Sgrna Editing Guides 100 Mer, Gmp-like, 1 Mg - Quantity 4 @ $2995.25/EACH = $11981.00$12K
Sep 2018Federal contractHealth and Human S · Synthego (ambis #1925946) Sgrna Target 2 100MER Gmp-like 8.34 Mg$25K
Aug 2018Federal contractHealth and Human S · Gene Editing Rna Guide - Quantity 1$25K
Nov 2017Federal contractHealth and Human S · Crisprevolution Sgrna Ez Kit (modified) 3NMOL$4K
Sep 2017Federal contractHealth and Human S · SYNTHEGO:1293873 [17-005566]$147K
Sep 2017Federal contractHealth and Human S · SYNTHEGO:1293873 [17-005624]$44K
Sep 2017Federal contractHealth and Human S · SYNTHEGO:1293873 [17-005567]$48K

Federal awards are summed by year (60 awards); hover a bar for the split. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Standing among 342 peers

Line = median

Biotech · Platform

Granted patents#18 · top 5%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

From SEC Form D filings

Drew John OettingDirectorNamed in SEC Form D filings
Forrest John Baringer-JonesExecutive OfficerNamed in SEC Form D filings
Michael Jakub DabrowskiExecutive Officer, DirectorNamed in SEC Form D filings
Paul John DabrowskiExecutive Officer, DirectorNamed in SEC Form D filings
Scott John NolanDirectorNamed in SEC Form D filings

What it has protected

USPTO · 14 granted of 40

Oct 2, 2025PendingConjugated Crispr-cas ComplexesUSPTOApplication 18833834
Sep 16, 2025GrantedSystems And Method For Automated Oligonucleotide SynthesisUSPTOUS 12,415,172
Jun 24, 2025GrantedGuide Rna Synthesis System And MethodUSPTOUS 12,337,291

Show all 40 patent records

Conjugated Crispr-cas ComplexesOct 2, 2025 · Application 18833834Pending
Systems And Method For Automated Oligonucleotide SynthesisSep 16, 2025 · US 12,415,172Granted
Guide Rna Synthesis System And MethodJun 24, 2025 · US 12,337,291Granted
Stabilized CRISPR ComplexesJan 9, 2025 · Application 18882590Pending
Methods And Systems For Automated Fraction Selection In Nucleic Acid ManufacturingJan 2, 2025 · Application 18743558Pending
Stabilized CRISPR ComplexesNov 12, 2024 · US 12,139,707Granted
Guide Rna Sequencing ConfirmationNov 7, 2024 · Application 18655927Pending
Cryogenically Arrayable Stable TransfectionAug 15, 2024 · Application 18441839Pending
Systems and Methods for Modulating CRISPR ActivityJun 27, 2024 · Application 18532892Pending
Genetically Modified Cells Expressing Antigen-Containing Fusion Proteins and Uses ThereofJun 6, 2024 · Application 18550205Pending
Cell Culture Laser PhotoablationApr 30, 2024 · US 11,970,685Granted
Methods For Analyzing Nucleic Acid SequencesApr 30, 2024 · US 11,970,733Granted
Methods and Systems for Guide RNA Design and UseMar 14, 2024 · Application 18235281Pending
Systems and Methods for Modulating CRISPR ActivityJan 30, 2024 · US 11,884,918Granted
Methods and Systems for Guide RNA Design and UseOct 31, 2023 · US 11,802,296Granted
Systems And Methods For Gene ModificationJul 11, 2023 · US 11,697,827Granted
Devices And Methods For Transfection And For Generation Of Clonal Populations Of CellsFeb 16, 2023 · Application 17793861Pending
Automated Modular System and Method for Production of BiopolymersOct 6, 2022 · Application 17849076Pending
Automated Modular System And Method For Production Of BiopolymersSep 13, 2022 · US 11,439,971Granted
Methods And Systems For Guide Rna Design And UseMay 31, 2022 · US 11,345,932Granted
Genetic Variant Panels And Methods Of Generation And Use ThereofJun 10, 2021 · Application 17174902Pending
Cell Culture Laser PhotoablationJun 8, 2021 · US 11,028,358Granted
Automated Modular System And Method For Production Of BiopolymersOct 27, 2020 · US 10,814,300Granted
Automated Modular System And Method For Production Of BiopolymersFeb 25, 2020 · US 10,569,249Granted
Biopolymer Synthesis System And MethodMar 14, 2019 · Application 16130901Pending
Automated Modular System And Method For Production Of BiopolymersAug 7, 2018 · US 10,040,048Granted
Arbitrary Waveform Electroporator Circuit And DeviceApplication 63426475Pending
Genetically Modified Polynucleotides And Cells Expressing Modified Mhc Proteins And Uses ThereofApplication PCTUS2023074240Pending
Consumable For Centrifugation Of Biological Cells With A Variable Collection Chamber For Supernatant RemovalApplication 63433056Pending
Apparatus And Methods For Microfluidic Handling Of Fluids Using Valve SystemsApplication 63424669Pending
Systems And Method For Automated Oligonucleotide SynthesisApplication 63434777Pending
Consumable For Centrifugation Of Biological CellsApplication PCTUS2023079344Pending
Conjugated Crispr-cas ComplexesApplication PCTUS2023061463Pending
Cryogenically Arrayable Stable TransfectionApplication 63445606Pending
Systems And Method For Automated Oligonucleotide SynthesisApplication 63445536Pending
Guide Rna Sequencing ConfirmationApplication 63500510Pending
Apparatus And Methods For Microfluidic Handling Of Fluids Using Valve SystemsApplication PCTUS2023079328Pending
Arbitrary Waveform Electroporator Circuit And DeviceApplication PCTUS2023079856Pending
Systems And Methods For Handling And Transferring Fluids Aseptically Via Microfluidic ComponentsApplication PCTUS2023021531Pending
Systems And Methods For Engageable Platforms And Modules For Cell ProcessingApplication PCTUS2023022484Pending

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Regulatory activity · Biotech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.