PROTAGONIST THERAPEUTICS, INC.
Narrative analysis and measurement software for understanding customer behavior patterns
- Sector
- Biotech
- Headquarters
- Milpitas, CA
- Latest Form D
- $17.5M, Jul 2015
- Total capital
- $28.8M
- Federal grants
- $4.3M
- 6 awards · 2015–2019
- Rank in peer group#206 of 514
- Private capital raised
- $24.5M
- 2 Form D · last Jul 2015
- 135 months since last filing
- Federal contracts
- None on recordNo federal contract awards found.
- Granted patents
- 13
- 27 pending · first 2022
- Rank in peer group#6 of 514
Capital timeline
Latest events
- Federal grantHealth and Human S · Phase II · Developing the required biomarkers that define ferroportin target engagement and impact on downstream signaling for clinical translation$693K
- Federal grantHealth and Human S · Phase II · Developing the required biomarkers that define ferroportin target engagement and impact on downstream signaling for clinical translation$1.5M
- Federal grantHealth and Human S · Phase II · Developing the required biomarkers that define IL-23R target engagement and effect on downstream signaling for late stage drug development and early clinical proof-of-concept$374K
- Federal grantHealth and Human S · Phase II · Developing the required biomarkers that define IL-23R target engagement and effect on downstream signaling for late stage drug development and early clinical proof-of-concept$1.3M
- Federal grantHealth and Human S · Phase I · Hepcidin Mimetics for the Treatment of Iron Overload Diseases$219K
- Federal grantHealth and Human S · Phase I · Orally delivered antagonists of Interleukin-23 receptor for treatment of inflammatory bowel disease$224K
- Private capital raisedForm D · SEC · 2nd filing$17.5M
- Private capital raisedForm D · SEC · 1st filing$7M
Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.
Standing among 514 peers
Line = medianBiotech · Molecule
- Federal grants#206 · top 40%
- Granted patents#6 · top 1%
- Linked publications#71 · top 14%
Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.
Founders and team
From SEC Form D filings- Armen ShanafeltDirectorNamed in SEC Form D filings
- Armen V. Shanafelt, Ph.D.DirectorNamed in SEC Form D filings
- Asish K. XavierDirectorNamed in SEC Form D filings
- Asish K. Xavier, Ph.D.DirectorNamed in SEC Form D filings
- Dinesh Patel, PhDExecutive Officer, DirectorNamed in SEC Form D filings
- Harold SelickDirectorNamed in SEC Form D filings
Show all 10 people
- Harold E. Selick, Ph.D.DirectorNamed in SEC Form D filings
- Michael K. Panaccio, Ph.D.DirectorNamed in SEC Form D filings
- Nicholas PeaceDirectorNamed in SEC Form D filings
- Paul F. TruexDirectorNamed in SEC Form D filings
What it has protected
USPTO · 13 granted of 40- PendingNovel A4B7 Thioether Peptide Dimer AntagonistsUSPTOApplication 19303188
- GrantedOral Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory Bowel DiseasesUSPTOUS 12,673,974
- GrantedPeptide Inhibitors Of INTERLEUKIN-23 And Their Use To Treat Inflammatory DiseasesUSPTOUS 12,655,185
Show all 40 patent records
- Novel A4B7 Thioether Peptide Dimer AntagonistsJul 30, 2026 · Application 19303188Pending
- Oral Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory Bowel DiseasesJul 7, 2026 · US 12,673,974Granted
- Peptide Inhibitors Of INTERLEUKIN-23 And Their Use To Treat Inflammatory DiseasesJun 16, 2026 · US 12,655,185Granted
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesApr 30, 2026 · Application 19421560Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesFeb 17, 2026 · US 12,552,836Granted
- Lipidated Peptide Inhibitors Of INTERLEUKIN-23 ReceptorJan 1, 2026 · Application 19248166Pending
- Hepcidin Mimetics For Treatment Of Sickle Cell DiseaseNov 27, 2025 · Application 18872323Pending
- Conjugated Hepcidin MimeticsNov 27, 2025 · Application 18834490Pending
- Lipidated Peptide Inhibitors Of INTERLEUKIN-23 ReceptorNov 25, 2025 · US 12,478,617Granted
- Hepcidin Analogues And Uses ThereofNov 6, 2025 · Application 19069557Pending
- Disulfide-rich Peptide Libraries And Methods Of Use ThereofOct 23, 2025 · Application 18999655Pending
- Conjugated Hepcidin MimeticsOct 2, 2025 · Application 19019120Pending
- Conjugated Hepcidin MimeticsSep 4, 2025 · Application 18284835Pending
- Conjugated Hepcidin MimeticsMay 29, 2025 · Application 18834495Pending
- Hepcidin Analogues And Uses ThereofApr 8, 2025 · US 12,269,856Granted
- Conjugated Hepcidin MimeticsFeb 25, 2025 · US 12,234,300Granted
- Peptide Inhibitors Of INTERLEUKIN-23 ReceptorDec 12, 2024 · Application 18579062Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesNov 21, 2024 · Application 18657493Pending
- Bicyclic Peptide Inhibitors Of INTERLEUKIN-23 ReceptorOct 24, 2024 · Application 18579033Pending
- Hepcidin Mimetics For Treatment Of Hereditary HemochromatosisSep 5, 2024 · Application 18570004Pending
- Peptide Inhibitors of Interleukin-23 ReceptorAug 22, 2024 · Application 18412678Pending
- Compositions Of Peptide Inhibitors Of INTERLEUKIN-23 ReceptorAug 1, 2024 · Application 18422878Pending
- Conjugated Hepcidin MimeticsJul 11, 2024 · Application 18285203Pending
- Conjugated Hepcidin MimeticsJun 27, 2024 · Application 18285198Pending
- A4B7 Thioether Peptide Dimer AntagonistsJun 27, 2024 · Application 18501864Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesJun 25, 2024 · US 12,018,057Granted
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesMay 9, 2024 · Application 18492612Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesApr 25, 2024 · Application 18097077Pending
- Compositions Of Peptide Inhibitors Of INTERLEUKIN-23 ReceptorMar 26, 2024 · US 11,939,361Granted
- Conjugated Hepcidin MimeticsFeb 29, 2024 · Application 18018481Pending
- Oral Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory Bowel DiseasesJan 30, 2024 · US 11,884,748Granted
- Hepcidin Mimetics For Treatment Of Sickle Cell DiseaseJan 18, 2024 · Application 18355992Pending
- Conjugated Hepcidin MimeticsJan 18, 2024 · Application 18018482Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesDec 19, 2023 · US 11,845,808Granted
- NOVEL a4B7 THIOETHER PEPTIDE DIMER ANTAGONISTSDec 12, 2023 · US 11,840,581Granted
- Hepcidin Analogues And Uses ThereofNov 7, 2023 · US 11,807,674Granted
- Conjugated Hepcidin MimeticsSep 21, 2023 · Application 18016825Pending
- Peptide Inhibitors Of INTERLEUKIN-23 Receptor And Their Use To Treat Inflammatory DiseasesApr 27, 2023 · Application 17792594Pending
- Conjugated Hepcidin MimeticsNov 24, 2022 · Application 17639138Pending
- Analogues Of Hepcidin Mimetics With Improved In Vivo Half LifesOct 18, 2022 · US 11,472,842Granted
Recent research by its founders
- Iron Restricted Erythropoiesis Under Hepcidin Mimetic Treatment (PN23114) Improved Disease Parameters in a Mouse Model for Sickle Cell Disease20230 cites
- Rusfertide Analog-PN23114 As a Hepcidin Mimetic Provides Efficacy Benefits in Conjunction with Phlebotomy in Mouse Model for Hereditary Hemochromatosis20223 cites
- PTG-100, an Oral α4β7 Antagonist Peptide: Preclinical Development and Phase 1 and 2a Studies in Ulcerative Colitis202136 cites
Related companies, and why
- Factor Medical, LLCSimilar federal contract value in Biotech · null in contracts
- DNATRIX INCSimilar federal contract value in Biotech · null in contracts
- Auvi Labs, Inc.Similar federal contract value in Biotech · null in contracts
- ADYNXX, INC.Similar federal contract value in Biotech · null in contracts
- Distributed Bio, Inc.Similar federal contract value in Biotech · null in contracts
- IQuity Labs, Inc.Similar federal contract value in Biotech · null in contracts
Regulatory activity · Biotech
- New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
- Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
- Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
- Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
- Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
- Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration
Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.
Sources
Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.
How to read this page
Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.
Data freshness
SEC Form D filings through . SBIR and STTR awards through .