PRIMROSE BIO, INC.
enzymatic DNA and RNA synthesis platform using template-independent DNA polymerases for manufacturing oligonucleotides
- Sector
- Biotech
- Headquarters
- SAN DIEGO, CA
- Founded
- 2023
- Latest Form D
- $15M, Jul 2024
- Total capital
- $19.6M
- Federal grants
- $4.6M
- 9 awards · 2017–2023
- Rank in peer group#6 of 36
- Private capital raised
- $15M
- 1 Form D · last Jul 2024
- 27 months since last filing
- Federal contracts
- None on recordNo federal contract awards found.
- Granted patents
- 1
- 14 pending · first 2026
- Rank in peer group#10 of 36
Capital timeline
Latest events
- Private capital raisedForm D · SEC · 1st filing$15M
- Federal grantHealth and Human S · Phase II · DNA 3.0: Development of a novel, efficient and cost-effective enzymatic process for synthesis of DNA oligonucleotides$984K
- Federal grantHealth and Human S · Phase II · DNA 3.0: Development of a novel, efficient and cost-effective enzymatic process for synthesis of DNA oligonucleotides$1.1M
- Federal grantHealth and Human S · Phase II · Development of superior polymerases for next-generation mRNA therapeutic & vaccine manufacturing$469K
- Federal grantHealth and Human S · Phase I · DNA 3.0: Developing novel enzymes for DNA synthesis with deep learning and combinatorial genetics$52K
- Federal grantHealth and Human S · Phase II · Development of superior polymerases for next-generation mRNA therapeutic & vaccine manufacturing$1.2M
- Federal grantHealth and Human S · Phase I · DNA 3.0: Developing novel enzymes for DNA synthesis with deep learning and combinatorial genetics$375K
Show 3 earlier federal awards
- Federal grantAgriculture · Boosting Methionine Levels For Enhanced Nutritional Profile Of Yeast Co-products Used In Animal Feed$100K
- Federal grantHealth and Human S · Phase I · Discovery and development of single-subunit RNA polymerases for efficient RNA manufacturing$225K
- Federal grantHealth and Human S · Phase I · Synthetic biology E. coli strain development for expression of functional human GPCRs with roles in human disease$225K
Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.
Federal first
79months
from PRIMROSE BIO, INC.’s first federal award to its first private round.
- First federal award · Dec 2017
- Health and Human S · $225K
- First Form D · Jul 2024
- $15M · 1st Form D
- Awards before first raise
- 9 awards
An association in public records, not a cause or a prediction.
Standing among 36 peers
Line = medianBiotech · Platform
- Federal grants#6 · top 17%
- Granted patents#10 · top 28%
Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.
Founders and team
Researcher links verified by same-company patents and grants- Helge ZielerResearcherDirector, Executive OfficerLinked by $4.3M in grants as PI
- J. Todd MitchellDirectorNamed in SEC Form D filings
- Matthew Todd KorenbergDirectorNamed in SEC Form D filings
- Matthew ReberDirectorNamed in SEC Form D filings
- Wes Todd KaupinenDirectorNamed in SEC Form D filings
What it has protected
USPTO · 1 granted of 15- GrantedMethods And Compositions For Manufacturing PolynucleotidesUSPTOUS 12,600,958
- PendingCompositions And Methods For Enzymatic Nucleic Acid SynthesisUSPTOApplication 18569883
- PendingCompositions And Methods For Enzymatic Nucleic Acid SynthesisUSPTOApplication 18569914
Show all 15 patent records
- Methods And Compositions For Manufacturing PolynucleotidesApr 14, 2026 · US 12,600,958Granted
- Compositions And Methods For Enzymatic Nucleic Acid SynthesisNov 21, 2024 · Application 18569883Pending
- Compositions And Methods For Enzymatic Nucleic Acid SynthesisSep 12, 2024 · Application 18569914Pending
- Rna Polymerases For Mrna ManufacturingApplication PCTUS2025043340Pending
- Rna Polymerases For Mrna ManufacturingApplication PCTUS2025043337Pending
- RNA POLYMERASE VARIANTS FOR mRNA MANUFACTURINGApplication 63687240Pending
- RNA POLYMERASE VARIANTS FOR mRNA MANUFACTURINGApplication 63687249Pending
- Methods And Compositions For Nucleic Acid SynthesisApplication 19471970Pending
- Methods And Compositions For Nucleic Acid SynthesisApplication PCTUS2024023441Pending
- Methods And Compositions For Protein EngineeringApplication PCTUS2024023460Pending
- Compositions And Methods For Enzymatic Nucleic Acid SynthesisApplication PCTUS2022033312Pending
- Compositions And Methods For Enzymatic Nucleic Acid SynthesisApplication PCTUS2022033313Pending
- RNA POLYMERASE VARIANTS FOR mRNA MANUFACTURINGApplication 63687235Pending
- Methods And Compositions For Protein EngineeringApplication 19471959Pending
- Rna Polymerases For Mrna ManufacturingApplication PCTUS2025043332Pending
Related companies, and why
- PhaseBio Pharmaceuticals IncSimilar federal contract value in Biotech · null in contracts
- STREAM BIOMEDICAL INCSimilar federal contract value in Biotech · null in contracts
- TWOXAR, INC.Similar federal contract value in Biotech · null in contracts
- XDEMICS CORPORATIONSimilar federal contract value in Biotech · null in contracts
- PURE GREEN PHARMACEUTICALS, INC.Similar federal contract value in Biotech · null in contracts
- KANO THERAPEUTICS INCSimilar federal contract value in Biotech · null in contracts
Regulatory activity · Biotech
- New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
- Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
- Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
- Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
- Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
- Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration
Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.
Sources
Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.
How to read this page
Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.
Data freshness
SEC Form D filings through . SBIR and STTR awards through .