ISOPLEXIS CORPORATION
Wilmington, DE · Founded 2013 · CIK 0001615055 · Medtech · Acquired
Single-cell proteomics chip and automated instrument (IsoCode Chip and IsoLight) that measures 40+ secreted proteins per cell to predict CAR-T cell therapy responders, non-responders, and toxicity ris
isoplexis.com →- Grants
- $26M
- 34 awards
- Sector median: 1
- Raised
- $127M
- 7 Form D · Jan 2021
- 68 months since last filing
- Contracts
- $684K
- 10 awards · Health and Human S, Agriculture, Veterans Affairs
- #357 of 4531 in medtech
- Patents
- 25
- 6 granted · 19 pending
- Sector median: 2
Capital Timeline
Federal ↑Equity ↓201420162018202020222024
| Date | Event | Source | Amount |
|---|---|---|---|
| Private capital raised | Form D · SEC | $1,301,432 | |
| Private capital raised | Form D · SEC | $2,350,000 | |
| Federal grant | Department of Health and Human Services · Phase I · A Single Cell Multi-Protein Device to Facilitate Cancer Immunotherapy | $181,989 | |
| Federal grant | Department of Health and Human Services · Phase I · A Single Cell Multi-Protein Device to Facilitate Cancer Immunotherapy | $181,989 | |
| Federal grant | Department of Health and Human Services · Phase I · Single-cell multi-protein device for informative cellular function evaluation | $164,031 | |
| Federal grant | Department of Health and Human Services · Phase I · Single-cell multi-protein device for informative cellular function evaluation | $164,031 | |
| Federal grant | Department of Health and Human Services · Phase I · A microchip to analyze trafficking leukocytes in Alzheimer’s disease patients | $164,016 | |
| Federal grant | Department of Health and Human Services · Phase I · A microchip to analyze trafficking leukocytes in Alzheimer’s disease patients | $164,016 | |
| Private capital raised | Form D · SEC | $5,745,000 | |
| Federal grant· 1 of 2 same day | Department of Health and Human Services · Phase I · Precision Quality Check of Immunotherapeutics via Single Cell Cytokine Mapping | $160,286 | |
| Federal grant· 2 of 2 same day | Department of Health and Human Services · Phase I · Precision Quality Check of Immunotherapeutics via Single Cell Cytokine Mapping | $160,286 | |
| Federal grant | Department of Health and Human Services · Phase I · Developing an integrated sorting and single cell analysis tool for the analysis of rare T Cells subsets in Autoimmunity | $162,533 | |
| Federal grant | Department of Health and Human Services · Phase II · Precision quality check of immunotherapeutics via single-cell cytokine mapping | $974,208 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease | $845,621 | |
| Private capital raised | Form D · SEC | $5,404,968 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics | $599,799 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics | $1,799,397 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell device to capture and analyze rare T-cells from solid tumors. | $991,227 | |
| Federal grant | Department of Health and Human Services · Phase II · Precision quality check of immunotherapeutics via single-cell cytokine mapping | $910,459 | |
| Federal grant | Department of Health and Human Services · Phase I · A High-Throughput, Multi-Omic Assay of Tumor Biomarkers from Single-Cells | $163,731 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-Cell Device to Detect Pathogenic Cell Populations in Bone Marrow Disease | $845,621 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell device to capture and analyze rare T-cells from solid tumors. | $920,072 | |
| Federal grant | Department of Health and Human Services · Phase I · A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery | $224,895 | |
| Federal grant | Department of Health and Human Services · Phase II · Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance | $224,633 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics | $599,799 | |
| Private capital raised | Form D · SEC | $19,649,842 | |
| Federal grant· 1 of 2 same day | Department of Health and Human Services · Phase II · A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies | $3,999,736 | |
| Federal grant· 2 of 2 same day | Department of Health and Human Services · Phase II · A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies | $1,699,322 | |
| Federal grant | Department of Health and Human Services · Phase II · Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance | $999,016 | |
| Federal grant | Department of Health and Human Services · Phase II · Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation | $996,470 | |
| Federal grant | Department of Health and Human Services · Phase II · A single-cell mouse proteomic system to accelerate pre-clinical immune therapeutics | $599,799 | |
| Federal grant | Department of Health and Human Services · Phase I · Age-dependent Single-cell Metabolomic and Proteomic Profiling of Human Immune System | $224,947 | |
| Federal grant | Department of Health and Human Services · Phase I · Age-dependent Single-cell Metabolomic and Proteomic Profiling of Human Immune System | $224,947 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies | $1,150,207 | |
| Federal contract | Department of Health and Human Services · Iso Light System | $99,998 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-cell Platform for Analyzing the Peripheral Immune Response in Alzheimer’s and Alzheimer’s Related Diseases | $999,615 | |
| Federal contract | Department of Health and Human Services · Covid 19 Isoplexis Reagents | $41,356 | |
| Federal grant | Department of Health and Human Services · Phase II · Single-cell Phosphoprotein Assay to Evaluate Brain Tumor Therapeutic Resistance | $961,259 | |
| Federal grant | Department of Health and Human Services · Phase II · Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation | $988,980 | |
| Private capital raised· 1 of 2 same day | Form D · SEC | $7,500,007 | |
| Private capital raised· 2 of 2 same day | Form D · SEC | $85,000,061 | |
| Federal contract | Department of Agriculture · Research Analysis Of Cytokine And Secretome For Testing Adaptive Immune Panel Of 15 Samples Of Chicken Serum. | $3,300 | |
| Federal contract | Department of Veterans Affairs · Isosplexis | $96,850 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-cell Platform for Analyzing the Peripheral Immune Response in Alzheimer’s and Alzheimer’s Related Diseases | $994,372 | |
| Federal contract | Department of Health and Human Services · An Automated Multiplex Live Single Cell Analysis Platform System Manufactured By Isoplexis | $126,420 | |
| Federal contract | Department of Veterans Affairs · Isospark System With Incidental Services And Acessories - Kc Vamc | $70,000 | |
| Federal grant | Department of Health and Human Services · Phase II · A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies | $1,150,207 | |
| Federal contract | Department of Veterans Affairs · Isoplexis Codeplex Chips And Panels | $29,678 | |
| Federal contract | Department of Health and Human Services · Codeplex Assay Processing Services (ambis #2124229) | $25,572 | |
| Federal contract | Department of Health and Human Services · Isoplexis Isospark Duo | $176,609 | |
| Federal contract | Department of Health and Human Services · Isospark Service Agreement | $14,081 |
Federal grant · SBIR/STTRFederal contract · USAspendingForm D · SEC
Peer position
| # | Company | Contracts | Disclosed equity |
|---|---|---|---|
| 354 | NANODROPPER INC | $712K | $1.1M |
| 355 | Aspira Women's Health Inc. | $696K | $80M |
| 356 | BIOPTIGEN, INC. | $686K | $1.5M |
| 357 | ISOPLEXIS CORPORATION | $684K | $127M |
| 358 | TearScience, Inc. | $681K | $59M |
| 359 | INVIVOSCIENCES, INC. | $679K | — |
| 360 | Sonica LLC | $656K | — |
Ranked on federal contract value rather than capital raised. The equity column is the comparison worth making — companies at the same procurement position often sit at very different points in their funding history.
Founders & Team
- John ConleyDirector
- MICHAEL EGHOLMDirector
- Rong FanDirector
- James HeathDirector
- JAMES HEATHDirector
- Gregory HoDirector
- GREGORY HODirector
- SHARON KEDARDirector
- Sean MackayDirector · Executive Officer
- Sean McKayDirector · Executive Officer
- John StrahleyExecutive Officer
- Daniel WagnerDirector
- DANIEL WAGNERDirector
Patents
- Methods And Devices For Sequencing Nucleic Acids In Smaller Batchesgranted
- Systems, Devices And Methods For Multiplexed Analysisgranted
- Systems, Devices And Methods For Cell Capture And Methods Of Manufacture Thereofapplication
- Systems, Devices And Methods For Cell Capture And Methods Of Manufacture Thereofgranted
- System And Methods For Multiplexed Analysis Of Cellular And Other Immunotherapeuticsgranted
- Analysis And Screening Of Cell Secretion Profilesapplication
- Analysis And Screening Of Cell Secretion Profilesgranted
- Compositions And Methods For The Simultaneous Genomic, Transcriptomic And Proteomic Analysis Of Single Cellsgranted
- Polymerase Enzyme From Phage T4application
- Polymerase Enzyme From 9°Napplication
- Methods And Compositions For Incorporating Nucleotidesapplication
- Methods And Compositions For Incorporating Nucleotidesapplication
Regulatory activity · Medtech
- New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
- Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
- Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
- Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
- Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
- Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration
Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.