ENCLEAR THERAPIES, INC.
A sensor-controlled cerebrospinal fluid (CSF) infusion system that precisely regulates drug delivery to the brain by modulating flow rate, direction, and concentration oscillation for CNS therapeutics
New patent ·
- Sector
- Medtech
- Headquarters
- CAMBRIDGE, MA
- Latest Form D
- $718K, Mar 2024
- Total capital
- $4.8M
- Federal grants
- $4.1M
- 6 awards · 2023–2025
- Rank in peer group#210 of 538
- Private capital raised
- $718K
- 1 Form D · last Mar 2024
- 32 months since last filing
- Federal contracts
- None on recordNo federal contract awards found.
- Granted patents
- 8
- 32 pending · first 2022
- Rank in peer group#74 of 538
Capital timeline
Latest events
- Federal grantHealth and Human S · Phase I · Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease$150K
- Federal grantHealth and Human S · Phase I · Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease$108K
- Federal grantHealth and Human S · Phase II · Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System$3M
- Federal grantHealth and Human S · Phase II · Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System$93K
- Federal grantHealth and Human S · Phase I · Smart CSF Delivery System for CNS Drug Therapy for Leptomeningeal Disease$296K
- Private capital raisedForm D · SEC · 1st filing$718K
- Federal grantHealth and Human S · Phase II · Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System$495K
Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.
Federal first
2months
from ENCLEAR THERAPIES, INC.’s first federal award to its first private round.
- First federal award · Dec 2023
- Health and Human S · $495K
- First Form D · Mar 2024
- $718K · 1st Form D
- Awards before first raise
- 1 award
An association in public records, not a cause or a prediction.
Standing among 538 peers
Line = medianMedtech · Device
- Federal grants#210 · top 39%
- Granted patents#74 · top 14%
Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.
Founders and team
Researcher links verified by same-company patents and grants- Anthony DePasquaResearcherExecutive Officer, DirectorLinked by 1 patent
- Jason CammDirectorNamed in SEC Form D filings
- Jonathan FlemingDirectorNamed in SEC Form D filings
- Kasper RoetDirectorNamed in SEC Form D filings
What it has protected
USPTO · 8 granted of 40- New patentSystem and Method for Controlling CSF Flow and Managing Intracranial PressureUSPTOUS 12,752,090
- GrantedCsf Diagnostics PlatformUSPTOUS 12,728,190
- PendingMethod And Apparatus For Determining Patency For An Intrathecal Access SiteUSPTOApplication 19215901
Show all 40 patent records
- System and Method for Controlling CSF Flow and Managing Intracranial PressureOct 6, 2026 · US 12,752,090Granted
- Csf Diagnostics PlatformSep 8, 2026 · US 12,728,190Granted
- Method And Apparatus For Determining Patency For An Intrathecal Access SiteNov 27, 2025 · Application 19215901Pending
- Methods Of Amelioration Of Cerebrospinal Fluid And Devices And Systems ThereforOct 9, 2025 · Application 19244447Pending
- Subarachnoid Fluid Management Method And System With Varying RatesSep 25, 2025 · Application 19231172Pending
- Subarachnoid Fluid Management Method And SystemSep 25, 2025 · Application 19230893Pending
- Methods of Amelioration of Cerebrospinal Fluid and Devices and Systems ThereforJul 8, 2025 · US 12,350,416Granted
- Subarachnoid Fluid Management Method And System With Varying RatesJun 24, 2025 · US 12,337,140Granted
- Subarachnoid Fluid Management Method And SystemJun 17, 2025 · US 12,329,930Granted
- Csf Therapeutic Delivery SystemAug 29, 2024 · Application 18590730Pending
- System And Method For Monitoring Physiological Parameters Based On Cerebrospinal Fluid Pressures Taken At Two Or More LocationsNov 9, 2023 · Application 18132174Pending
- System And Method For Managing Cancer Cells In CsfOct 12, 2023 · Application 18125059Pending
- Methods Of Treating Neurological DisordersSep 12, 2023 · US 11,752,200Granted
- Methods Of Treating Neurological DisordersFeb 23, 2023 · Application 17815619Pending
- Csf Diagnostics PlatformNov 10, 2022 · Application 17868484Pending
- Method Of Regulating Gene ExpressionOct 6, 2022 · Application 17848211Pending
- Methods Of Treating Neurological DisordersAug 23, 2022 · US 11,419,921Granted
- System and Method for Controlling CSF Flow and Managing Intracranial PressureApr 7, 2022 · Application 17495682Pending
- Subarachnoid Fluid Conduit System And KitMar 31, 2022 · Application 17489633Pending
- Methods of Amelioration of Cerebrospinal Fluid and Devices and Systems ThereforMar 22, 2022 · US 11,278,657Granted
- Rate Of Regeneration LiquorpheresisApplication 63322511Pending
- System And Method For Managing Csf FlowsApplication 63328579Pending
- System And Method For Controlling Csf Flow And Managing Intracranial PressureApplication PCTUS2021053829Pending
- Method Of Regulating Gene ExpressionApplication PCTUS2022034706Pending
- Csf Diagnostics PlatformApplication PCTUS2022037609Pending
- CSF SystemApplication 63449019Pending
- System And Method For Managing Cancer Cells In CsfApplication PCTUS2023015972Pending
- Subarachnoid Fluid Management Method And SystemApplication PCTUS2021052735Pending
- Csf Diagnostics PlatformApplication 63223248Pending
- Fluid Management SystemApplication 63214239Pending
- System And Method For Monitoring Physiological Parameters Based On Cerebrospinal Fluid Pressures Taken At Two Or More LocationsApplication PCTUS2023017893Pending
- Csf Therapeutic Delivery SystemApplication PCTUS2024017736Pending
- System And Method Of Treating Neurological DisordersApplication PCTUS2021013458Pending
- Subarachnoid Fluid Management SystemApplication 63117975Pending
- Systems, Devices, And Methods Of Fluid Management And Drug DeliveryApplication 63088401Pending
- Method And Apparatus For Determining PatencyApplication 63650842Pending
- Subarachnoid Fluid Management SystemApplication 63084996Pending
- Methods Of Amelioration Of Cerebrospinal Fluid And Devices And Systems ThereforApplication PCTUS2020027683Pending
- Methods Of Treating Neurological DisorderApplication 62960861Pending
- Methods Of Treating Neurological DisordersApplication PCTUS2019042880Pending
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Regulatory activity · Medtech
- New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
- Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
- Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
- Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
- Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
- Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration
Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.
Sources
Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.
How to read this page
Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.
Data freshness
SEC Form D filings through . SBIR and STTR awards through .