Design-Zyme LLC

Lawrence, KS · Medtech · Still private

Enzyme engineering platform that stabilizes dehydrogenases for use in amperometric biosensors, with initial application to cortisol monitoring

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Updated Oct 23, 2026

Sector: Medtech
Headquarters: Lawrence, KS
Total capital: $1.5M

Federal grants: $1.5M; 6 awards · 2018–2020; Rank in peer group#16 of 28
Private capital raised: None on recordNo Form D filings on SEC EDGAR. Some raises are not filed.
Federal contracts: None on recordNo federal contract awards found.
Granted patents: 3; 10 pending · first 2021; Rank in peer group#3 of 28

Capital timeline

Latest events

Aug 2020Federal grantHealth and Human S · Phase I · A Cortisol Sensing Enzyme System: A New Platform Utilizing Dehydrogenases in Biosensors$252K
Jul 2020Federal grantHealth and Human S · Phase I · A Cortisol Sensing Enzyme System: A New Platform Utilizing Dehydrogenases in Biosensors$252K
May 2020Federal grantHealth and Human S · Phase I · In Vitro Enzyme Glycosylation:A New Platform for Enzyme Stabilization$252K
Apr 2020Federal grantHealth and Human S · Phase I · In Vitro Enzyme Glycosylation: A New Platform for Enzyme Stabilization$252K
Sep 2018Federal grantHealth and Human S · Phase I · Development of a Wearable Band-Aid Biosensor System for Alcohol Monitoring$375K
Jun 2018Federal grantHealth and Human S · Phase I · Isolation and Identification of Prebiotic Nutrient Components$150K

Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Standing among 28 peers

Line = median

Medtech · Molecule

Federal grantsBelow median
Granted patents#3 · top 11%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

No founders are linked to this company yet.

Founders appear once a person is matched to the company through its own patents, grants or filings. We never infer people from social profiles.

Checked: USPTO inventors; federal award principal investigators; SEC Form D related persons · Oct 23, 2026

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What it has protected

USPTO · 3 granted of 13

Oct 23, 2025PendingVaccine CompositionUSPTOApplication 19256289
Oct 16, 2025PendingUniversal Adjuvant For Nasal, Oral, And Intramuscular Delivery Of VaccinesUSPTOApplication 18869181
Oct 8, 2024GrantedIn Vitro Glycosylation Of Proteins And EnzymesUSPTOUS 12,110,532

Show all 13 patent records

Vaccine CompositionOct 23, 2025 · Application 19256289Pending
Universal Adjuvant For Nasal, Oral, And Intramuscular Delivery Of VaccinesOct 16, 2025 · Application 18869181Pending
In Vitro Glycosylation Of Proteins And EnzymesOct 8, 2024 · US 12,110,532Granted
Self-adjuvanting Multi-protein Complexes For Modular Vaccine ProductionMay 16, 2024 · Application 18499765Pending
Universal Adjuvant For Nasal, Oral, And Intramuscular Delivery Of VaccinesMay 2, 2024 · Application 18196214Pending
In Vitro Glycosylation Of Proteins And EnzymesMay 9, 2023 · US 11,643,676Granted
In Vitro Glycosylation Of Proteins And EnzymesJun 1, 2021 · US 11,021,730Granted
Universal Adjuvant for Nasal, Oral, and Intramuscular Delivery of VaccinesApplication 63365432Pending
In Vitro Glycosylation Of Proteins And EnzymesApplication PCTUS2018066407Pending
In Vitro Glycosylation of Enzymes and Protein TherapeuticsApplication 62607655Pending
Universal Adjuvant For Nasal, Oral, And Intramuscular Delivery Of VaccinesApplication PCTUS2023023550Pending
Self-adjuvanting Multi-protein Complexes For Modular Vaccine ProductionApplication PCTUS2023078438Pending
Self-adjuvanting Multi-protein Complexes For Modular Vaccine ProductionApplication 63382020Pending

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Regulatory activity · Medtech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.