Combinati Incorporated

Palo Alto, CA · Founded 2015 · Medtech · Acquired

Digital Melt Curve Analysis (DMCA) platform for nucleic acid quantification and mutation detection

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Updated Oct 23, 2026 · combinati.com

Sector: Medtech
Headquarters: Palo Alto, CA
Founded: 2015
Latest Form D: $5.8M, May 2018
Total capital: $13.7M

Federal grants: $7.9M; 15 awards · 2016–2021; Rank in peer group#252 of 538
Private capital raised: $5.8M; 1 Form D · last May 2018; 101 months since last filing
Federal contracts: None on recordNo federal contract awards found.
Granted patents: 14; 26 pending · first 2017; Rank in peer group#43 of 538

Capital timeline

Latest events

Apr 2021Federal grantHealth and Human S · Phase II · Digital Melt Curve Analysis Platform for Longitudinal Cancer Patient Monitoring$773K
Mar 2021Federal grantHealth and Human S · Phase II · Digital Melt Curve Analysis Platform for Longitudinal Cancer Patient Monitoring$773K
Jul 2020Federal grantHealth and Human S · Phase II · Array Imaging digital PCR Platform$600K
Jul 2019Federal grantHealth and Human S · Phase II · Array Imaging digital PCR Platform$600K
Mar 2019Federal grantHealth and Human S · Phase I · Integrated Microbial Screening and Antimicrobial Susceptibility Test on Microfluidic Digital Array for Diagnosis of Urinary Tract Infections$225K
Aug 2018Federal grantHealth and Human S · Phase II · Array Imaging digital PCR Platform$600K
Aug 2018Federal grantHealth and Human S · Phase II · Array Imaging digital PCR Platform$1.8M
May 2018Private capital raisedForm D · SEC · 1st filing$5.8M

Show 8 earlier federal awards

Jul 2018Federal grantHealth and Human S · Phase I · Single-color Multiplexed Digital PCR via High Resolution Melt Analysis of Endpoint Digital PCR Partitions$225K
Apr 2018Federal grantHealth and Human S · Phase I · High Density Array Digital PCR for Cancer Rare Mutation Quantification$225K
Mar 2018Federal grantHealth and Human S · Phase I · High Density Array Digital PCR for Cancer Rare Mutation Quantification$225K
Jun 2017Federal grantHealth and Human S · Phase I · Integrated Digital PCR Platform with a Micromolded Siphoning Array$350K
Mar 2017Federal grantHealth and Human S · Phase I · Micromolded Digital Nucleic Acid Test Consumable$215K
Feb 2017Federal grantHealth and Human S · Phase I · Micromolded Digital Nucleic Acid Test Consumable$215K
Jun 2016Federal grantHealth and Human S · Phase I · Integrated Digital PCR Platform with a Micromolded Siphoning Array$700K
Jun 2016Federal grantHealth and Human S · Phase I · Integrated Digital PCR Platform with a Micromolded Siphoning Array$350K

Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Federal first

23months

from Combinati Incorporated’s first federal award to its first private round.

First federal award · Jun 2016: Health and Human S · $350K
First Form D · May 2018: $5.8M · 1st Form D
Awards before first raise: 7 awards

An association in public records, not a cause or a prediction.

Standing among 538 peers

Line = median

Medtech · Device

Federal grants#252 · top 47%
Granted patents#43 · top 8%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

Researcher links verified by same-company patents and grants

Ju-Sung (Paul) HungResearcherExecutive Officer, DirectorLinked by $2.8M in grants as PI
Charles CollinsDirectorNamed in SEC Form D filings
Michael MokelkeDirectorNamed in SEC Form D filings

What it has protected

USPTO · 14 granted of 40

Feb 17, 2026GrantedMicrofluidic Siphoning Array For Nucleic Acid QuantificationUSPTOUS 12,551,890
Nov 11, 2025GrantedMicrofluidic Array For Sample DigitizationUSPTOUS 12,465,915
Jul 1, 2025GrantedOptical System, And Method Of Illuminating A Sample PlaneUSPTOUS 12,345,642

Show all 40 patent records

Microfluidic Siphoning Array For Nucleic Acid QuantificationFeb 17, 2026 · US 12,551,890Granted
Microfluidic Array For Sample DigitizationNov 11, 2025 · US 12,465,915Granted
Optical System, And Method Of Illuminating A Sample PlaneJul 1, 2025 · US 12,345,642Granted
Devices And Methods For Sample ProcessingJun 17, 2025 · US 12,330,151Granted
Microfluidic DeviceMay 13, 2025 · US D1,075,047Granted
Systems And Methods For Polymerase Chain Reaction QuantificationApr 24, 2025 · Application 18691571Pending
Methods And Systems For Nucleic Acid Analysis AndquantificationApr 3, 2025 · Application 18827365Pending
Microfluidic DeviceMar 18, 2025 · US D1,067,460Granted
Microfluidic Device And Method For Processing Biological SamplesNov 14, 2024 · Application 18691223Pending
Methods And Systems For Nucleic Acid Analysis And QuantificationSep 17, 2024 · US 12,091,711Granted
Microfluidic Siphoning Array For Nucleic Acid QuantificationApr 9, 2024 · US 11,951,478Granted
Devices And Methods For Sample PartitioningFeb 22, 2024 · Application 18269893Pending
Systems And Methods For Analyte AnalysisFeb 22, 2024 · Application 18269896Pending
Systems And Methods For Analyzing A Biological SampleNov 2, 2023 · Application 18002310Pending
Methods And Systems For Nucleic Acid Analysis And QuantificationJul 11, 2023 · US 11,697,844Granted
Methods And Systems For Microfluidic Device ManufacturingFeb 2, 2023 · Application 17759070Pending
Optical System, and Method of Illuminating a Sample PlaneJan 31, 2023 · US 11,567,007Granted
Microfluidic Siphoning Array For Nucleic Acid QuantificationMar 29, 2022 · US 11,285,478Granted
Microfluidic Siphoning Array For Nucleic Acid QuantificationJul 1, 2021 · Application 17028839Pending
Microfluidic Siphoning Array For Nucleic Acid QuantificationJan 2, 2020 · Application 16270457Pending
Methods And Systems For Nucleic Acid Analysis And QuantificationDec 31, 2019 · US 10,519,494Granted
Microfluidic Siphoning Array For Nucleic Acid QuantificationApr 9, 2019 · US 10,252,266Granted
Microfluidic Siphoning Array For Nucleic Acid QuantificationDec 19, 2017 · US 9,845,499Granted
Systems And Methods For Analyzing A Biological SampleApplication PCTUS2021038206Pending
Systems And Methods For Analyte AnalysisApplication 63173038Pending
Devices And Methods For Sample ProcessingApplication PCTUS2021052206Pending
Methods And Systems For Microfluidic Device ManufacturingApplication PCTUS2021014558Pending
Systems And Methods For Analyte AnalysisApplication 63131473Pending
Devices And Methods For Sample PartitioningApplication 63131513Pending
Devices For Sample ProcessingApplication 63084271Pending
Microfluidic Device And Method For Processing Biological SamplesApplication PCTUS2022043544Pending
Microfluidic DevicesApplication 63549048Pending
Systems And Methods For Analyzing A Biological SampleApplication 63042353Pending
Systems And Methods For Analyte AnalysisApplication PCTUS2021065361Pending
Methods And Systems For Microfluidic Devices ManufacturingApplication 62965690Pending
Microfluidic Array For Sample DigitizationApplication PCTUS2019065287Pending
Devices And Methods For Sample PartitioningApplication PCTUS2021065397Pending
Microfluidic Siphoning Array For Nucleic Acid QuantificationApplication PCTUS2019025539Pending
Microfluidic Array For Sample DigitizationApplication 62777616Pending
Microfluidic Siphoning Array For Nucleic Acid QuantificationApplication 62652859Pending

Third Pole, Inc.Similar federal contract value in Medtech · null in contracts
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Tetra Discovery Partners, Inc.Similar federal contract value in Medtech · null in contracts
Corfigo, Inc.Similar federal contract value in Medtech · null in contracts
Onconano Medicine, Inc.Similar federal contract value in Medtech · null in contracts
AdvancedCPR Solutions LLCSimilar federal contract value in Medtech · null in contracts

Regulatory activity · Medtech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.