ALPHATHERA

Bryn Mawr, PA · Biotech · Private

Biological reagent platform that delivers antibodies into cells and triggers intracellular protein degradation via TRIM21 E3 ubiquitin ligase engagement

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Updated Oct 23, 2026 · alphathera.com

Sector: Biotech
Headquarters: Bryn Mawr, PA
Total capital: $5M

Federal grants: $4.9M; 11 awards · 2017–2022; Rank in peer group#157 of 392
Private capital raised: None on recordNo Form D filings on SEC EDGAR. Some raises are not filed.
Federal contracts: $150K; 1 award · Health and Human S; Rank in Biotech#306 of 4373
Granted patents: 0; 11 pending

Capital timeline

Latest events

Jun 2022Federal grantHealth and Human S · Phase II · Generation of antibody-drug conjugates by proximity-based sortase-mediated ligation$611K
Aug 2021Federal grantHealth and Human S · Phase II · TABA: Tools for the site-specific labeling and immobilization of antibodies for immunoassays$50K
Jun 2021Federal grantHealth and Human S · Phase II · Generation of antibody-drug conjugates by proximity-based sortase-mediated ligation$1.1M
Sep 2020Federal grantHealth and Human S · Phase II · An ELISA and homogeneous assay for serological diagnosis of SARS-CoV2 antibodies$120K
Aug 2020Federal grantHealth and Human S · Phase II · An ELISA and homogeneous assay for serological diagnosis of SARS-CoV2 antibodies$547K
Mar 2020Federal grantHealth and Human S · Phase I · TRIM21-mediated degradation of antibody-targeted cytosolic proteins$271K
Mar 2020Federal grantHealth and Human S · Phase I · TRIM21-mediated degradation of antibody-targeted cytosolic proteins$271K

Show 5 earlier federal awards

Jul 2019Federal grantHealth and Human S · Phase II · Tools for the site-specific labeling and immobilization of antibodies for immunoassays$696K
Sep 2018Federal contractHealth and Human S · SBIR Topic 105, Phase I, Reagent Development For Small Cell Number Chic-seq$150K
Jul 2018Federal grantHealth and Human S · Phase II · Tools for the site-specific labeling and immobilization of antibodies for immunoassays$764K
Aug 2017Federal grantHealth and Human S · Phase I · Preparation of site-specific antibody-drug conjugates by proximity-based sortase ligation$225K
Mar 2017Federal grantHealth and Human S · Phase I · Tools for site-specific antibody immobilization for immunoassays$225K

Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Standing among 392 peers

Line = median

Biotech · Molecule

Federal grants#157 · top 40%
Linked publications#15 · top 4%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

No founders are linked to this company yet.

Founders appear once a person is matched to the company through its own patents, grants or filings. We never infer people from social profiles.

Checked: USPTO inventors; federal award principal investigators; SEC Form D related persons · Oct 23, 2026

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What it has protected

USPTO · 0 granted of 11

Feb 12, 2026PendingPHOTOREACTIVE ANTIBODY-BINDING DOMAIN FOR SITE-SPECIFIC MODIFICATION OF THE ANTIGEN BINDING FRAGMENT (Fab) OF IgG AND IgMUSPTOApplication 19099699
Apr 24, 2025PendingPhotoreactive Antibody Binding Domains With Epitope Tags For Multiplexed Antibody Labeling, Detection, And PurificationUSPTOApplication 18681488
Jan 23, 2025PendingAffinity Purification, Proximity-based Sortase Ligation, And Detection Of Proteins With Precursor Peptides And B1 Proteins From Lasso Peptide Biosynthesis SystemsUSPTOApplication 18716935

Show all 11 patent records

PHOTOREACTIVE ANTIBODY-BINDING DOMAIN FOR SITE-SPECIFIC MODIFICATION OF THE ANTIGEN BINDING FRAGMENT (Fab) OF IgG AND IgMFeb 12, 2026 · Application 19099699Pending
Photoreactive Antibody Binding Domains With Epitope Tags For Multiplexed Antibody Labeling, Detection, And PurificationApr 24, 2025 · Application 18681488Pending
Affinity Purification, Proximity-based Sortase Ligation, And Detection Of Proteins With Precursor Peptides And B1 Proteins From Lasso Peptide Biosynthesis SystemsJan 23, 2025 · Application 18716935Pending
METHODS AND COMPOSITIONS THEREOF FOR SITE-SPECIFIC LABELING OF HUMAN IgG BY PROXIMITY-BASED SORTASE-MEDIATED LIGATIONJul 11, 2024 · Application 18559333Pending
Precise Labeling Of Protein Scaffolds With Cargo For Use In Biomedical ApplicationsApr 11, 2024 · Application 18254851Pending
METHODS AND COMPOSITIONS THEREOF FOR SITE-SPECIFIC LABELING OF HUMAN IgG BY PROXIMITY-BASED SORTASE-MEDIATED LIGATIONApplication 63185843Pending
Precise Labeling Of Protein Scaffolds With Cargo For Use In Biomedical ApplicationsApplication 63119644Pending
PHOTOREACTIVE ANTIBODY-BINDING DOMAIN FOR SITE-SPECIFIC MODIFICATION OF THE ANTIGEN BINDING FRAGMENT (Fab) OF IgG AND IgMApplication 63396411Pending
Methods And Compositions Thereof For Site-specific Labeling Of Human Igg By Proximity-based Sortase-mediated LigationApplication PCTUS2022028134Pending
Affinity Purification, Proximity-based Sortase Ligation, And Detection Of Proteins With Precursor Peptides And B1 Proteins From Lasso Peptide Biosynthesis SystemsApplication 63288483Pending
Precise Labeling Of Protein Scaffolds With Cargo For Use In Biomedical ApplicationsApplication PCTUS2021061228Pending

Recent research by its founders

Eco-friendly energy management strategy for turbo-electric eVTOLs: Coupling fuel economy, battery health and life-cycle emissions via improved TD320262 cites
Light‐Driven Cobalt Size Modulation on Boron Nitride Enables On‐Demand Reactive Oxygen Species Programming20262 cites
An Offline Multi-objective Energy Management Strategy for Turbo-electric Hybrid Propulsion System Using Few Computational Time20260 cites

REGIS TECHNOLOGIES INCSimilar federal contract value in Biotech · $160K in contracts
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EVAS THERAPEUTICS LLCSimilar federal contract value in Biotech · $150K in contracts
RESPIRERX PHARMACEUTICALS INC.Similar federal contract value in Biotech · $149K in contracts

Regulatory activity · Biotech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.