ADVANTAGE THERAPEUTICS, INC

Miami, FL · Founded 2021 · Biotech · Private

Small-molecule therapeutic for Alzheimer's disease targeting amyloid pathology

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Updated Oct 23, 2026 · advantagetherapeutics.com

Sector: Biotech
Headquarters: Miami, FL
Founded: 2021
Latest Form D: $10.2M, Jul 2023
Total capital: $18M

Federal grants: $2.5M; 2 awards · 2025–2026; Rank in peer group#426 of 514
Private capital raised: $15.5M; 3 Form D · last Jul 2023; 40 months since last filing
Federal contracts: None on recordNo federal contract awards found.
Granted patents: 2; 7 pending · first 2021; Rank in peer group#142 of 514

Capital timeline

Latest events

Jun 2026Federal grantHealth and Human S · Phase II · AD04 disease-modifying drug for Alzheimer's - preclinical and IND-enabling studies$1.2M
Sep 2025Federal grantHealth and Human S · Phase II · AD04 disease-modifying drug for Alzheimer's - preclinical and IND-enabling studies$1.2M
Jul 2023Private capital raisedForm D · SEC · 3rd filing$10.2M
Jun 2022Private capital raisedForm D · SEC · 2nd filing$275K
Jun 2021Private capital raisedForm D · SEC · 1st filing$5M

Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Standing among 514 peers

Line = median

Biotech · Molecule

Federal grantsBelow median
Granted patents#142 · top 28%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

From SEC Form D filings

Agustin Fernandez Santana IIIExecutive Officer, DirectorNamed in SEC Form D filings
David B. BuchsbaumExecutive OfficerNamed in SEC Form D filings
Frank B. MattnerDirectorNamed in SEC Form D filings
James B. O'NeillDirectorNamed in SEC Form D filings
Jeffrey B. MaddenDirectorNamed in SEC Form D filings
Walter B. SchmidtDirectorNamed in SEC Form D filings

What it has protected

USPTO · 2 granted of 9

Jul 2, 2026PendingIncreasing Klotho LevelsUSPTOApplication 18863897
May 9, 2024PendingTreatment And Prevention Of Alzheimer's Disease (ad)USPTOApplication 18514612
Jan 2, 2024GrantedTreatment And Prevention Of Alzheimer's Disease (ad)USPTOUS 11,857,568

Show all 9 patent records

Increasing Klotho LevelsJul 2, 2026 · Application 18863897Pending
Treatment And Prevention Of Alzheimer's Disease (ad)May 9, 2024 · Application 18514612Pending
Treatment And Prevention Of Alzheimer's Disease (ad)Jan 2, 2024 · US 11,857,568Granted
Treatment Of Alzheimer's Disease (ad) With An Aluminum SaltMar 3, 2022 · Application 17482579Pending
Treatment Of Alzheimer's Disease (ad) With An Aluminum SaltOct 19, 2021 · US 11,147,873Granted
Nucleic Acid Encoding Klotho For Use In Therapeutic And Non-therapeutic Methods For Reducing Body WeightApplication 19527664Pending
Klotho MrnaApplication PCTUS2024021148Pending
Increasing Klotho LevelsApplication PCTUS2023066721Pending
Klotho MrnaApplication 19165686Pending

Cour PharmaceuticalSimilar federal contract value in Biotech · null in contracts
Paragon Bioservices, Inc.Similar federal contract value in Biotech · null in contracts
BASEPAIR, INC.Similar federal contract value in Biotech · null in contracts
ENVISAGENICS INCSimilar federal contract value in Biotech · null in contracts
Quralis CorporationSimilar federal contract value in Biotech · null in contracts
Scribe Therapeutics Inc.Similar federal contract value in Biotech · null in contracts

Regulatory activity · Biotech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.