ACTIVE MOTIF, INC.
Epi-Seq, a high-throughput multiplexed ChIP-Seq platform for genome-wide epigenetic profiling combining automated chromatin preparation (PIXUL sonicator) with transposase-assisted multiplex sequencing
- Sector
- Biotech
- Headquarters
- Carlsbad, CA
- Latest Form D
- $10M, Sep 2021
- Total capital
- $20.8M
- Federal grants
- $4.3M
- 9 awards · 2015–2025
- Rank in peer group#13 of 36
- Private capital raised
- $13.6M
- 2 Form D · last Sep 2021
- 61 months since last filing
- Federal contracts
- $2.9M
- 123 awards · Veterans Affairs, Health and Human S, Agriculture
- Rank in Biotech#111 of 4373
- Granted patents
- 4
- 9 pending · first 2018
- Rank in peer group#5 of 36
Capital timeline
Latest events
- Federal grantHealth and Human S · Phase I · A Novel Epigenetic Editing Platform$306K
- Federal contractVeterans Affairs · Tobacman's Study Utilizing Atac-seq, And Rna-seq -active Motif$22K
- Federal contractAgriculture · Service Contract For A Contractor That Is Able To Provide Reagents And Perform Assay To Assess Dna Associated With H3K27ACEYLATED Chromatin (cut&tag) In Bovine Monocytes.$44K
- Federal contractHealth and Human S · Active Motif (ambis #2233008) Sequencing Services$14K
- Federal contractHealth and Human S · Reagents - Atac-seq Kit, 16 Rxns$15K
- Federal contractHealth and Human S · 24-003842 The Lab Requires Chip-seq And Rna-seq In Order To Analyze Gene Expression$7K
- Federal grantHealth and Human S · Phase I · Novel Integrated Platform to Quantitate Rejuvenation in vivo$314K
- Private capital raisedForm D · SEC · 2nd filing$10M
- Private capital raisedForm D · SEC · 1st filing$3.6M
Show 123 earlier federal awards
- Federal contractHealth and Human S · Active Motif, INC.:1107110 [24-000121] Please See Items Biological Materials$17K
- Federal contractHealth and Human S · Active Motif (ambis #2190532) Rna And End-to-end Rna Sequencing Services$13K
- Federal contractHealth and Human S · Active Motif End-to-end Rna-seq Service, Including Bioinformatic Analysis, Custom Assay: Rna-seq Sample Submission In Rlt Buffer$13K
- Federal contractHealth and Human S · Single-nuclei Multiome Analysis Of Human Brain Tissue, Ipsc-derived Cells And Human Dorsal Root Ganglion.$405K
- Federal contractHealth and Human S · Factorpath Chip-seq, Histonepath And Input-seq.$310K
- Federal contractAgriculture · Project: Atac-seq$129K
- Federal contractHealth and Human S · Acquisition Of One (1) Active Motif Pixul Multi-sample Sonicator For The Dhhs, NIH, Nci, Ccr$75K
- Federal contractHealth and Human S · Analysis Of Accessible Chromatin Regions During Induced Pluripotent Stem Cell (ipsc) Cell Culture$22K
- Federal contractHealth and Human S · These Experiments Are Necessary Before We Can Validate The Hypothesis And Publish A Paper To Report Our Findings In Ovarian Cancer.$13K
- Federal contractHealth and Human S · Factor Path Analysis Service.$32K
- Federal contractHealth and Human S · Pixul Multi-sample Sonicator$75K
- Federal contractHealth and Human S · Needed For Experiments So The Elnitski Lab Can Validate The Hypothesis And Publish A Paper To Report Our Findings In Ovarian Cancer. [21-007141]$12K
- Federal contractHealth and Human S · Sequencing Scientific Supplies , INC.:1107110 [21-007601]$18K
- Federal contractHealth and Human S · Chip-seq Analysis Of Tobacco Related Compound Treatment In Human Endothelial Cells$15K
- Federal contractHealth and Human S · Chip-seq Analysis Of Tobacco Related Compound Treatment Of Human Endothelial Cells$24K
- Federal contractHealth and Human S · The Purpose Of This Requirement Is To Procure Facropath Chip-seq-services. Period Of Performance: 9/1/2020-8/31/2021.$10K
- Federal contractHealth and Human S · For Sequencing And Bioinformatics Analysis/factor Path Services [20-006430]$12K
- Federal contractHealth and Human S · Active Motif, INC.:1107110 [20-008037]$34K
- Federal contractHealth and Human S · Rna Sequencing Service For One Year$24K
- Federal contractAgriculture · Purchase Fugene® Hd Transfection 32042 And 32043 Reagents In Support Of Ongoing Research At Nea Piadc Located In Orient Ny 11957.$43K
- Federal grantHealth and Human S · Phase II · Epi-seq: Multiplexed ChIP-seq for personalized medicine and drug discovery$648K
- Federal contractHealth and Human S · Active Motif, INC.:1107110 [20-007967]$14K
- Federal contractHealth and Human S · Chip-seq Pull Down And Sequencing And Bioinformatics Analysis.$16K
- Federal contractHealth and Human S · Lab Chief Requires Chip-seq Service In Order To Study The Expression Of Target Genes.$14K
- Federal contractHealth and Human S · Rime Assays$12K
- Federal grantHealth and Human S · Phase II · Epi-seq: Multiplexed ChIP-seq for personalized medicine and drug discovery$1.8M
- Federal contractHealth and Human S · Atac-seq (no. 25079), Qty: 70. Atac-seq Sample Validation (no. 25087), Qty: 1. Histonepath Chip-seq (no. 25011), Qty: 70. Input-seq (no. 25046) Qty: 1. Methylpath Medip-seq (no. 25025), Qty: 70. Mod Spec (no. 25085), Qty: 70. Rrbs (no. 25069), Qty: 7$70K
- Federal contractHealth and Human S · Uterine Tissue Chip Seq$27K
- Federal contractVeterans Affairs · Lab Services$26K
- Federal contractHealth and Human S · Chip Sequence For Yap And Tead In Keratinocytes. Quote As Attached$14K
- Federal contractHealth and Human S · Analysis Of The Genomic Methylation Status Of Hpsc And Ipsc$78K
- Federal contractHealth and Human S · Histopath Sequencing Services Quantity Of 48 Samples$54K
- Federal contractAgriculture · Purchase Atac-sequencing And Chip-sequencing Service (rumen Epithelial Primary Cells) By Activemotif In Support Of Ongoing Research At Nea Animal Genomics And Improvement Located At 10300 Baltimore Avenue, Bldg 005, Room 306, Barc-west Beltsville, Md 20705.$32K
- Federal contractHealth and Human S · Chromatin Immunoprecipitation (chip) Sequence Service$62K
- Federal contractHealth and Human S · Custom Chip Service$15K
- Federal grantHealth and Human S · Phase II · Epi-seq: Multiplexed ChIP-seq for personalized medicine and drug discovery$279K
- Federal contractDefense · Igf::ot::igf Mod Spec T Services - New Base Award For Clinical Investigation At Tamc FY18$25K
- Federal contractHealth and Human S · Atac-seq Atac Sequencing Of 9 Cell Lines Catalog#: 25079$16K
- Federal contractHealth and Human S · Chip Sequencing -custom$14K
- Federal contractHealth and Human S · Chip Sequencing$15K
- Federal contractHealth and Human S · Chip Sequence Service$22K
- Federal contractHealth and Human S · Custom Dna Sequencing On Cblx Disorderquantity Of 3 Samples @ $4,740.00QUANTITY Of 1 Control Sample Of $1.750.00$16K
- Federal contractHealth and Human S · Igf::ot::igf Active MOTIF:1107110 [18-006553]$5K
- Federal contractHealth and Human S · Igf::cl,ct::igf$12K
- Federal contractAgriculture · "igf::ot::igf" Atac-sequencing And Chip-sequencing Service$35K
- Federal contractHealth and Human S · Igf::ot::igf Mouse Uterine Chromatin Landscaping Sample Analysis Services$32K
- Federal contractHealth and Human S · Igf::ot::igf$5K
- Federal grantHealth and Human S · Phase I · FFPE histone enrichment for antibody and mass spectrometry analysis of post translational modifications in epigenetic biomarker discovery$225K
- Federal contractHealth and Human S · Igf::ot::igf - Active MOTIF:1107110 [17-013737] Replaces Requisition 4721649INVOICE And Payment Provisionsthe Following Invoice And Payment Provisions Clause Is Applicable To All Purchase Orders, Task/delivery Orders And Bpa Calls: I. Invoice Requirementsa. An Invoice Is The Vendor's Bill Or Written Request For Payment Under The Contract For Supplies Delivered Or Services Performed. A Proper Invoice Is An "original" Which Must Include The Items Listed In Bullets 1 Through 11 Below. If The I$15K
- Federal contractHealth and Human S · Ambis 1859038 Factorpath Chip-seq; HCF1 Chip-seq For 4 Mouse Fibroblast Cell Lines; Product Code: 25001$38K
- Federal contractHealth and Human S · Activemotif Global Dna Methylation Kit$9K
- Federal contractHealth and Human S · Igf::ot::igf "evaluation Of Mouse Uterine Chromatin Landscape" - The Contractor Shall Provide All Personnel, Equipment, Supplies, Facilities, Transportation, Tools, Materials, Supervision, And Other Items And Non-personal Services Necessary To Perform Chip-seq Tasks As Defined In This Statement Of Work. Poa: Unmet Needs: Yao/brown: Active Motif: Quote # 00030836. Pls. Contact David Bullard For Release Of Funds.$28K
- Federal contractHealth and Human S · Igf::ot::igf Identify Binding Sites Of Androgen Receptor In The Genome.$9K
- Federal grantHealth and Human S · Phase I · Method for de novo Discovery of Locus Specific Regulatory Elements$225K
- Federal contractHealth and Human S · Chemicals$5K
- Federal grantHealth and Human S · Phase I · Multi-epitope tag (MET)-recombinant antibody toolbox for detection and manipulation of RNA modifications$225K
- Federal contractHealth and Human S · Igf::ot::igf "identify Binding Sites Of NR2F2 In The Genome Of Fetal Reproductive Organs"$11K
- Federal contractHealth and Human S · Igf::ot::igf - Active MOTIF:1107110 [16-011191]$19K
- Federal contractHealth and Human S · Igf::ot::igf Epigenetic Services$50K
- Federal contractHealth and Human S · Active Motif Lightswitch Promoter Vectors$5K
- Federal contractHealth and Human S · Active MOTIF:1107110 [16-000990]$6K
- Federal contractHealth and Human S · Igf::ot::igf Sequencing$57K
- Federal contractVeterans Affairs · Chip-it High Sensitivity Kits And Associated Antibodies Testing.$6K
- Federal contractHealth and Human S · Laboratory Equipment And Supplies$16K
- Federal grantHealth and Human S · Phase I · Neurobiology toolbox for identification of lncRNA targets and associated proteins$224K
- Federal contractHealth and Human S · Igf::ot::igf - 53051 - Epishear Probe Sonicator, 110V$5K
- Federal contractHealth and Human S · Igf::ot::igf Medical- Laboratory Testing$19K
- Federal contractHealth and Human S · Active Motif Q800R Sonicator, 110V, 110V (53062)$15K
- Federal contractHealth and Human S · Igf::ot::igf/factorpath Chip Sequencing$30K
- Federal contractHealth and Human S · Active MOTIF:1107110 [13-010577]$3K
- Federal contractHealth and Human S · TAS:75 0884:TAS O-glcnac And Rna Polii Chip-seq With C. Elegans. Reference Your Quote #16710$23K
- Federal contractHealth and Human S · Antibody Qualification. Quote # 16685$5K
- Federal contractHealth and Human S · TAS::75 0884::TAS ~ Pots 12-008467 (NIH Ref#s) Quote No.: 16332 ~ Catalog# 25011 ~ Des: Histonepath Chip-seq ~ Units: 5 ~ Price: $5,400.00 ~ User: Lothar Henninghausen$27K
- Federal contractHealth and Human S · TAS::75 0884::TAS Pots# 12-008468. Quote# 16333. Catalog# 25011. Histonepath Chip-seq (5). Requestor: Gertraud Robinson, Bldg 8, Rm 101. Pa: Amanda Chandler, 301-402-0569.$27K
- Federal contractHealth and Human S · TAS::75 0884::TAS Transcription Path Chip Sequencing Using Rna Pol II Phospho Ser 2 Quote # 100903-2 TAS::75 0884::TAS$10K
- Federal contractHealth and Human S · TAS::75 0884::TAS Factor Path Chip Sequencing Of Mouse Embryonic Stem Cells Quote # 100903-1 TAS::75 0884::TAS$12K
- Federal contractHealth and Human S · - Factorpath Chip-seq, Transcription Path, And Sequencing Of Input$51K
- Federal contractHealth and Human S · TAS::75 0884::TAS Factor Path Chip-seq. Quote # 15982.$14K
- Federal contractHealth and Human S · TAS::75 0884::TAS Pots# 11-010660. Quote# 14708. Catalog# 25011. Histonepath Chip-seq. Requestor: Gertraud Robinson, Bldg 8, Rm 107. Pa: Amanda Chandler, 301-402-0569.$28K
- Federal contractHealth and Human S · FY2011 Unmet Needs - Dr. Sylvia Hewitt/lrdt (korach)/ Active Motif Chip-seq Analysis; Can 1-8469986$52K
- Federal contractHealth and Human S · Chromatin Isolation&processing. Far 52.213-4 Terms&conditions Apply.$35K
- Federal contractVeterans Affairs · Chemicals$4K
- Federal contractVeterans Affairs · Research Order$3K
- Federal contractHealth and Human S · SBIR Topic 264 - (phase 1) The Goal Of This Project Is To Develop A Commercial Kit To Enable Academic And Clinical Researchers Working With A Wide Range Of Disease Models To Evaluate Locus-specific Methylation.$143K
- Federal contractHealth and Human S · Cit/dcb - Aks Software And Maintenance Option Year 1 Per Attached Quotes 5/1/09 - 4/30/09 Ref: Order No. HHSN276200800283P$10K
- Federal contractHealth and Human S · Active Motif Anual Support Contract; Maintenance Agreement.$15K
- Federal contractVeterans Affairs · Small Purchase Data$2K
- Federal contractVeterans Affairs · Small Purchase Data$265
- Federal contractVeterans Affairs · Small Purchase Data$280
- Federal contractVeterans Affairs · Small Purchase Data$425
- Federal contractVeterans Affairs · Small Purchase Data$340
- Federal contractVeterans Affairs · Small Purchase Data$340
- Federal contractVeterans Affairs · Small Purchase Data$995
- Federal contractVeterans Affairs · Small Purchase Data$2K
- Federal contractVeterans Affairs · Small Purchase Data$525
- Federal contractVeterans Affairs · Small Purchase Data$2K
- Federal contractVeterans Affairs · Small Purchase Data$440
- Federal contractVeterans Affairs · Small Purchase Data$2K
- Federal contractVeterans Affairs · Small Purchase Data$435
- Federal contractVeterans Affairs · Chip-it Express Enzymatic$768
- Federal contractVeterans Affairs · Nuclear Extract Kit$430
- Federal contractVeterans Affairs · Transam AP-1 Family$2K
- Federal contractVeterans Affairs · Nuclear Extract Kit, Reagent Kits$2K
- Federal contractVeterans Affairs · Nuclear Extract Kit #40010 (100 Reactions)$225
- Federal contractVeterans Affairs · Nuclear Extract Kit$405
- Federal contractVeterans Affairs · Chip-it Enzymatic W/o Control$455
- Federal contractVeterans Affairs · Trans Am Nfkb P65$675
- Federal contractVeterans Affairs · Chip It Express$875
- Federal contractVeterans Affairs · Clip-it Express Kit$425
- Federal contractVeterans Affairs · Transam Nfkb Family, 2 X 96 Rxns, 3 For Dr. Kudsk;$1K
- Federal contractVeterans Affairs · AP2 Gamma Polyclonal Antibody$545
- Federal contractVeterans Affairs · Rabbit Anti EZH2$340
- Federal contractVeterans Affairs · Trans Am Pcreb$1K
- Federal contractVeterans Affairs · Chip-it Express Enzymatic$502
- Federal contractVeterans Affairs · Buffer, Binding B-1$115
- Federal contractHealth and Human S · Cit - AKS2 Software$33K
- Federal contractVeterans Affairs · Nuclear Extract Kit$225
- Federal contractVeterans Affairs · Cat# AM-0174-200 ANTI-TRIMETHYL-LYS27 200UL$340
- Federal contractVeterans Affairs · Chip It Express Enzymedic$465
- Federal contractVeterans Affairs · Dna Damage Assay (fluorescent) For Dr. Zhong$3K
- Federal contractVeterans Affairs · Nushift AP-1 Family Kit$941
- Federal contractVeterans Affairs · Transam Nf-kb$2K
- Federal contractVeterans Affairs · Chip-it Express Enzymatic$445
Federal awards are summed by year (130 awards); hover a bar for the split. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.
2 records have no date or no amount, so they aren’t placed on the timeline.
Federal first
64months
from ACTIVE MOTIF, INC.’s first federal award to its first private round.
- First federal award · Nov 2007
- Veterans Affairs · $445
- First Form D · Mar 2013
- $3.6M · 1st Form D
- Awards before first raise
- 53 awards
An association in public records, not a cause or a prediction.
Standing among 36 peers
Line = medianBiotech · Platform
- Federal grants#13 · top 36%
- Granted patents#5 · top 14%
- Linked publications#5 · top 14%
Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.
Founders and team
Researcher links verified by same-company patents and grants- Joseph M FernandezResearcherExecutive Officer, DirectorLinked by 1 patent
- Alan S RichExecutive Officer, DirectorNamed in SEC Form D filings
- August S SickDirectorNamed in SEC Form D filings
- Bart S ChallisExecutive OfficerNamed in SEC Form D filings
- Charlie M McAteeDirectorNamed in SEC Form D filings
- Gerard S ShielsExecutive OfficerNamed in SEC Form D filings
Show all 15 people
- Jianxun M. LiDirectorNamed in SEC Form D filings
- Marc M. NasoffDirectorNamed in SEC Form D filings
- Mary M. JanatpourDirectorNamed in SEC Form D filings
- Owen M DempseyDirectorNamed in SEC Form D filings
- Patrick YountExecutive OfficerNamed in SEC Form D filings
- Stephanie M. LivaDirectorNamed in SEC Form D filings
- Tammy M. BrachDirectorNamed in SEC Form D filings
- Theodore M DeFrankExecutive Officer, DirectorNamed in SEC Form D filings
- Yasuhiro S YogoExecutive OfficerNamed in SEC Form D filings
What it has protected
USPTO · 4 granted of 13- GrantedTargeted Transposition For Use In Epigenetic StudiesUSPTOUS 12,049,622
- PendingMethods And Kits For The Enrichment And Detection Of Dna And Rna Modifications And Functional MotifsUSPTOApplication 17616147
- PendingMethods and Kits for Detection of N-4-acetyldeoxycytidine in DNAUSPTOApplication 17616149
Show all 13 patent records
- Targeted Transposition For Use In Epigenetic StudiesJul 30, 2024 · US 12,049,622Granted
- Methods And Kits For The Enrichment And Detection Of Dna And Rna Modifications And Functional MotifsMay 26, 2022 · Application 17616147Pending
- Methods and Kits for Detection of N-4-acetyldeoxycytidine in DNAMay 26, 2022 · Application 17616149Pending
- Targeted Transposition For Use In Epigenetic StudiesApr 19, 2022 · US 11,306,307Granted
- Targeted Transposition For Use In Epigenetic StudiesJun 23, 2020 · US 10,689,643Granted
- Multiplex Isolation Of Protein-associated Nucleic AcidsApr 10, 2018 · US 9,938,524Granted
- Targeted Transposition For Use In Epigenetic StudiesApplication PCTUS2014039250Pending
- Methods And Kits For Detection Of N-4-ACETYLDEOXYCYTIDINE In DnaApplication PCTUS2020066741Pending
- Methods and materials for mapping nucleic acids and associated features through targeted hybridization recruitmentApplication 63557976Pending
- Methods And Kits For The Enrichment And Detection Of Dna And Rna Modifications And Functional MotifsApplication PCTUS2020066986Pending
- Targeted Hybridization RecruitmentApplication PCTUS2025017417Pending
- Methods and Kits for Detection of N-4-acetyldeoxycytidine in DNAApplication 62953062Pending
- Methods and Kits for the Enrichment and Detection of DNA and RNA Modifications and Functional Motifs (Anchored Base-Sequencing - AB-seq)Application 62953080Pending
Recent research by its founders
- Abstract 1742: A universal spike-in normalization strategy for CUT&RUN, CUT&Tag and ATAC-seq20240 cites
- Abstract 3099: A new HTS ELISA for monitoring NRAS activity to expedite drug discovery20240 cites
- Generation of targeted antibody conjugates using Sortase and the AbFlex technology platform.20240 cites
Related companies, and why
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Regulatory activity · Biotech
- New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
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- Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
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- Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
- Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration
Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.
Sources
Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.
How to read this page
Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.
Data freshness
SEC Form D filings through . SBIR and STTR awards through .