21st Century Medicine, Inc.

Fontana, CA · Medtech · Private

Vitrification system for cryopreservation of whole human ovaries, including cryoprotective agent solutions, perfusion apparatus, and storage units

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Updated Oct 23, 2026 · 21cm.com

Sector: Medtech
Headquarters: Fontana, CA
Total capital: $3M

Federal grants: $3M; 5 awards · 2018–2021; Rank in peer group#358 of 538
Private capital raised: None on recordNo Form D filings on SEC EDGAR. Some raises are not filed.
Federal contracts: None on recordNo federal contract awards found.
Granted patents: 2; 12 pending · first 2023; Rank in peer group#190 of 538

Capital timeline

Latest events

Aug 2021Federal grantHealth and Human S · Phase II · Whole Ovary Vitrification for Fertility Preservation$721K
Sep 2020Federal grantHealth and Human S · Phase II · Whole Ovary Vitrification for Fertility Preservation$1.6M
Sep 2019Federal grantHealth and Human S · Phase I · Development of Novel Storage Method for Highly Viable and Well-Characterized Vitrified Human Islets$296K
Sep 2018Federal grantHealth and Human S · Phase I · Whole Ovary Vitrification for Fertility Preservation$173K
Sep 2018Federal grantHealth and Human S · Phase I · Development of Apparatus for the Vitrification of Curative Doses of Human Islets for Transplantation$220K

Node area is scaled to amount. Form D reports securities sold, which can differ from an announced round; filings are numbered in the order they were made.

Standing among 538 peers

Line = median

Medtech · Device

Federal grantsBelow median
Granted patents#190 · top 35%
Linked publications#14 · top 3%

Cumulative measures favor older companies. Rankings describe position today, not outcome. Below the median, ranks show as a band rather than a number.

Founders and team

No founders are linked to this company yet.

Founders appear once a person is matched to the company through its own patents, grants or filings. We never infer people from social profiles.

Checked: USPTO inventors; federal award principal investigators; SEC Form D related persons · Oct 23, 2026

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What it has protected

USPTO · 2 granted of 14

Dec 26, 2023GrantedMethods For Introduction And Prolonged Washout By Organ Perfusion Of Maximally Vitrifiable Cryoprotectant Solutions At Elevated TemperaturesUSPTOUS 11,849,719
May 30, 2023GrantedMethod Of Introduction And Removal Of High Concentrations Of Cryoprotectants By Vascular PerfusionUSPTOUS 11,659,835
Dec 3, 2020PendingCryogenic Storage System With Improved Temperature StabilityUSPTOApplication 16496642

Show all 14 patent records

Methods For Introduction And Prolonged Washout By Organ Perfusion Of Maximally Vitrifiable Cryoprotectant Solutions At Elevated TemperaturesDec 26, 2023 · US 11,849,719Granted
Method Of Introduction And Removal Of High Concentrations Of Cryoprotectants By Vascular PerfusionMay 30, 2023 · US 11,659,835Granted
Cryogenic Storage System With Improved Temperature StabilityDec 3, 2020 · Application 16496642Pending
Method And Apparatus For Ultra-rapid Preparation Of Corneas For VitrificationApplication 63390074Pending
Cryogenic Storage System With Improved Temperature StabilityApplication PCTUS2017058580Pending
Methods For Introduction And Prolonged Washout By Organ Perfusion Of Maximally Vitrifiable Cryoprotectant Solutions At Elevated TemperaturesApplication PCTUS2017043561Pending
Method Of Introduction And Removal Of High Concentrations Of Cryoprotectants By Vascular PerfusionApplication PCTUS2015042424Pending
Methods And Compositions For The Cryopreservation Of OrgansApplication PCTUS2004030544Pending
Cryogenic Storage SystemApplication PCTUS2004018601Pending
Polyglycerol And Lactose Compositions For The Protection Of Living Systems Form States Of Reduced MetabolismApplication PCTUS2003002939Pending
Prevention Of Toxicity From High Concentrations Of Cryoprotective AgentsApplication PCTUS2025021187Pending
Method And Apparatus For Ultra-rapid Preparation Of Corneas For VitrificationApplication 18997012Pending
Prevention Of Toxicity From High Concentrations Of Cryoprotective AgentsApplication 63569191Pending
Method And Apparatus For Ultra-rapid Preparation Of Corneas For VitrificationApplication PCTUS2023070435Pending

Recent research by its founders

Ultrastructural and Histological Cryopreservation of Mammalian Brains by Vitrification20260 cites
55 MHz constant field dielectric warming of kidneys and ovaries cryopreserved by vitrification202511 cites
In Memoriam - William F. Rall: Impacting science, impacting people20250 cites

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Regulatory activity · Medtech

Sector-level, not company-level

07 Jul 2026New Animal Drugs; Approval of New Animal Drug Applications; Withdrawal of Approval of New Animal Drug Application; Change of SponsorFood and Drug Administration
30 Jun 2026Medical Devices; General and Plastic Surgery Devices; Classification of the Skin Patch for Treatment of HyperhidrosisFood and Drug Administration
30 Jun 2026Medical Devices; Anesthesiology Devices; Classification of the Monitor for Opioid Induced Impairment of OxygenationFood and Drug Administration
29 Jun 2026Medical Devices; Orthopedic Devices; Classification of the Medial Knee Implanted Shock AbsorberFood and Drug Administration
26 Jun 2026Medical Devices; Neurological Devices; Classification of the External Lower Extremity Nerve Stimulator for Restless Legs SyndromeFood and Drug Administration
26 Jun 2026Medical Devices; General Hospital and Personal Use Devices; Classification of the Infant Supine Sleep SystemFood and Drug Administration

Rules are matched to sector, not to company. Recent activity in a sector is context rather than a signal about this business — until rules are matched to what a company actually builds, the section is shown as context and nothing more.

Sources

Federal grants from SBIR/STTR, NIH, NSF and DoD records. Federal contracts from USAspending.gov. Private capital from SEC Form D. Patents from USPTO. Publications from OpenAlex. Regulatory activity from the Federal Register. Press matched on company name.

How to read this page

Figures show associations in public records, not causes or predictions. Nothing here is investment advice. An em-dash means no record was found under this company's name, not that none exists.

Data freshness

SEC Form D filings through Oct 23, 2026. SBIR and STTR awards through Oct 21, 2026.